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OptumRx = UHC's PBM OptumRx is UnitedHealthcare's pharmacy benefit manager (PBM) the company that manages prescription drug coverage for UHC plans

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In clinical trials, people on Tirzepatide experienced an average weight loss of 15.3% after a year, compared to 8.3% for those on Semaglutide

Lu M, Cho E, Taylor A, Hankinson SE, Willett WC, Jacques PF

Patients not on treatment or on other antihyperglycemic agents entered a run-in treatment period of up to 12 weeks duration with metformin monotherapy (dose of greater than or equal to 1500 mg per day) which included washout of medications other than metformin, if applicable

Multiple imputation will be used for missing data