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[ref][ref][ref][ref] NLRP3 inflammasome: In addition to studies showing that higher levels of TNF and IL-8 are likely involved in fibromyalgia, studies have also shown that the NLRP3 inflammasome is activated.[ref] (This ties into the Lifehacks section and the clinical trials on supplements targeting NLRP3.) Mast cells: As part of the first line of defense against foreign pathogens and allergens, mast cells are often involved in increasing inflammation in certain tissues

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