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Patients who already have kidney diseases have to be watched closely

For preventing side effects caused by valproic acid (Depacon, Depakene, Depakote, VPA): 150-500 mg/kg has been taken daily

J Med Soc (2017) 31:185

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That suggests that lower-dose strategies can still affect metabolic markers, but randomized trials directly comparing labeled titration with microdosing protocols are lacking

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