4.6 Regulation of cellular signaling pathways OS in nerve injury and damage is closely linked to several signaling pathways that mediate cellular responses (Figure 2)
Upon binding, IGF-1R activates two downstream pathways: the PI3K/Akt pathway (driving protein synthesis and glucose uptake) and the MAPK/ERK pathway (promoting cell proliferation and differentiation)
Animal models and relevance to clinical practice
Although flavonoids contribute to stress protection through antioxidant activity, signaling modulation, and defense functions, their biosynthesis requires substantial investments of adenosine triphosphate (ATP), reducing equivalents, phenylalanine, acetyl-CoA, and malonyl-CoA that could otherwise support primary metabolism, respiration, osmotic adjustment, or reproductive development (Dixon and Paiva, 1995
Sen CK: Cellular thiols and redox-regulated signal transduction
aureus and S