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High blood sugar and obesity contribute to inflammation in fat tissue

New England Journal of Medicine, March 2023 In this Perspective piece, researchers at Vanderbilt University create a series of estimates about how much Medicare may have to spend annually on weight-loss drugs if the program eventually covers these drugs

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In a landmark double-blind, placebo-controlled crossover study of 20 men with psychogenic and organic erectile dysfunction, Melanotan II induced penile erections in 17 of 20 subjects (85%) in the absence of sexual stimulation

Glutathione depletion and a corresponding increase in reactive oxygen species (ROS) during microbial infection is a key driver of the immune response and inflammation

In conclusion, as we demonstrate here, the fusion of peptide therapeutics to an albumin-binding DARPin, if engineered properly, is a straightforward and modular protein engineering strategy to enhance the therapeutic efficacy of short-circulating biologics