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To date, there is a distinct lack of high-quality human IBD trial data validating its safety or efficacy
found "no adverse effects on blood clinical safety markers" in their 8-week study with resistance-trained males
All extended protocols require ongoing medical supervision to ensure continued safety and appropriate therapeutic use
In short, the side effects are mostly witnessed in the sensitive skin type
Early analyses suggest that retatrutide produces a body composition shift comparable to tirzepatide, where approximately 25-35% of total weight loss comes from lean mass and 65-75% from fat mass
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