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Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)
In clinical trial protocols, retatrutide followed a structured dose-escalation schedule designed to minimise gastrointestinal side effects the most commonly reported adverse effects with this class of medication
10.3390/nu11051104 258
Dev Neurosci
GIP GLP-1
Endocrinology 152 , 13471354 (2011)
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