Available information derives from animal studies or from mechanistic reasoning
works as intended
Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation
A 2018 study reported that administering 5-Amino-1MQ to diet-induced obese mice, at the dose defined in the study protocol over an 11-day period, was associated with reduced body weight, decreased adipose mass, and lowered plasma cholesterol without reduced food intake, pointing to altered energy handling
The defining 2018 Biochemical Pharmacology study reported a methylquinolinium NNMT inhibitor reducing body weight, white-fat mass and adipocyte size in diet-induced obese mice without changing food intake, while raising intracellular NAD+ and SAM [1]
Be sure to consult a healthcare professional to find out what dose is appropriate for you
