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Although immune dysfunction is clear in ME/CFS, further studies using defined cohorts, standardised assays, and new technologies are required to determine specific patterns (488), contradicting the hypothesis that ME/CFS could be caused by a clearance failure of the pathogenic microbe (99, 107)

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The nanoreactors can catalyze the oxidation of glutathione (GSH) to glutathione disulfide (GSSG) in hypoxic cancer cells

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