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JAMAs Post JAMA 222,264 followers Report this post Use of GLP-1 agonists for weight loss, compared with use of bupropion-naltrexone, was associated with an increased risk of pancreatitis, gastroparesis, and bowel obstruction but not biliary disease

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For more stubborn cases, a short-term stimulant like senna can get things moving, but its not ideal as a long-term crutch. Another option is taking 400 milligrams of magnesium oxide before bed