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Zhu H et al

Over time, this might cause allergic reactions or reduced effectiveness as the body develops antibodies

Vitamin B12 is water-soluble, meaning your body eliminates excess through urine rather than storing it to potentially toxic levels
Thomas, L

This method was noted for its pain-free and well-tolerated nature compared to intramuscular (IM) injections (3)

This is also why B12 deficiency sometimes mimics premature aging in the skin