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Moreover, IGF-IR activation is a mechanism underpinning the resistance to CDK4/6 inhibitor in Ewing sarcoma [132]

Meta-analysis of genome-wide association studies for height and body mass index in approximately 700000 individuals of European ancestry

Cell Res 30:146162

Oral administration of US FDA approved DPP-4 inhibitors, such as Saxagliptin, Vildagliptin, Anagliptin, etc., prolongs the half-lives and thus the action of GLP-1 and GIP, which in turn improves glycemic control with minimal risk of hypoglycemia (Havale and Pal, 2009)

Presented at the 2011 International Diabetes Federation World Diabetes congress

This really comes down to safety and effectiveness