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in animal models it is associated with tendon, ligament and muscle repair, angiogenesis and cytoprotection
However, researchers have compared the impact of both drugs from different studies (this is called an indirect analysis) and suggested that the higher doses (10mg and 15mg) of tirzepatide might reduce HbA1c by 0.36% more than 2mg of semaglutide
It is chemically a small-molecule, non-peptide compound rather than a true peptide, even though it is routinely grouped alongside peptides such as ipamorelin or CJC-1295 in bodybuilding content because it acts on the same GH/ghrelin pathway
Although direct clinical investigations specifically addressing SGLT2 inhibitor-polyphenol interactions remain scarce, accumulating theoretical frameworks and preliminary experimental observations warrant clinical vigilance
This is not to bash them, but to keep from putting them on an impossible pedestal that is bound to disappoint