K., Zinman, B., Choi, H., Connelly, P
In MS, GSH metabolism is impaired in regions of the CNS that have been demyelinated and correlates with mitochondrial dysfunction and axonal injury (Ferreira et al., 2013)
An NNMT inhibitor like 5-amino-1MQ could help by stimulating the synthesis of NAD+, a vital cofactor in the electron transport chain
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Meanwhile, Zealand Pharma is advancing petrelintide, a long-acting analog that in a Phase Ib study showed a promising efficacy and safety profile
It acts as a mediator that converts these harmful elements into water-soluble forms and thus enables them to be excreted via the kidneys