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Mechanism of action (MOA): Metformin help to control blood glucose level by reducing hepatic glucose production by activating AMPK enzyme and by increasing insulin sensitivity it increasing glucose uptake in muscle and fat tissue
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Nature 379 , 632635 (1996)
Primary Cellular Pathways Triple Incretin Receptor Activation Metabolic Regulation GLP3 functions as a triple agonist simultaneously activating GLP-1R, GIPR, and GCGR with distinct potency profiles[1]
Whilst gastritisinflammation of the stomach liningis not specifically listed as a recognised adverse effect in the Summary of Product Characteristics, Wegovy commonly causes gastrointestinal symptoms that may mimic gastric discomfort
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