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In a healthy heart, between 70% to 90% of cardiac ATP is produced by fatty acid oxidation [16,17]
The development of GLP-1 receptor agonists for type 2 diabetes was contextualised within the broader research landscape, including orally bioavailable agonists, allosteric modulators, and unimolecular multi-agonists all of which use the native GLP-1 receptor as their primary target
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For some people, pursuing weight loss can be harmful, for instance by leading to weight cycling or increasing the risk of developing an eating disorder
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