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Likewise, Long-term questions include gallbladder events associated with rapid weight loss, pancreatitis signals, clinically significant dehydration, effects on heart rate or blood pressure, nutritional insufficiency, psychiatric outcomes, immunogenicity, and safety in people with severe gastrointestinal disease, advanced kidney or liver disease, pregnancy, or multiple interacting medications

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As a consequence, the gluten-free diet, essential for individuals with celiac disease, has been proposed in recent years as a healthy dietary model also in non-coeliac individuals [141]

For instance, studies have observed a significant reduction of wrinkle volume, with some research indicating reductions of over 30% compared to other active compounds and over 50% compared to control serum

Notably, when semaglutide was tested in patients with MASH-related compensated cirrhosis in a phase II placebo-controlled trial, Loomba et al