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Gross morphology and histological analysis of the liver revealed a worse phenotype in HFD-APAP-treated mice compared to controls, with clear necrotic areas and massive accumulation of large lipid droplets as indicated by H&E and Oil Red O staining, respectively (Fig

TMAO producer phenotypes are distinguished by their gut microbiome profiles Because the participants TMAO productivity was partially increased by carnitine supplementation, the gut microbial community may also have been altered

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This occurs when there's an imbalance between the generation and buildup of reactive oxygen species (ROS) within cells and tissues and the ability of innate biological systems and dietary antioxidants to eliminate these reactive byproducts

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