glp-1 drugs history Timeline of discovery and clinical development. (a) Key events in GLP-1s like Ozempic transformed weight

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The benefit of GLP-1 RAs exceeded the harms for weight loss in the first 2 years of treatment, yet the net benefit was dependent on individual treatment goals (10% or 5% weight loss) and willingness to accept harms in pursuit of weight loss

Choline Choline plays a vital role in babys brain development and helps to prevent abnormalities of the brain and spine

Haddad M, Perrotte M, Ben KMR et al (2019) Methylglyoxal and glyoxal as potential peripheral markers for mci diagnosis and their effects on the expression of neurotrophic, inflammatory and neurodegenerative factors in neurons and in neuronal derived-extracellular vesicles

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Iyer TK, Manson JE