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The strategy was, therefore, to identify GLP-1 mimetic drugs with a molecular structure close enough to native GLP-1 to stimulate the GLP-1 receptor, but with alterations that enabled prolonged activity by, in particular, possessing resistance to breakdown by DPP-4 (Meier, 2012)

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Phase 2 data published in The New England Journal of Medicine in 2023 suggest meaningful weight reductions can begin within the first few months of treatment, with results continuing to build over 48 weeks

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