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Inform patients of the signs and symptoms of acute kidney injury and instruct them to promptly report any of these signs or symptoms or persistent (or extended) nausea, vomiting, and diarrhea to their healthcare provider [see Warnings and Precautions ( 5.5 )]

Tips for managing diarrhea Drink extra fluids so you do not get dehydrated Avoid greasy, spicy, and high-fat foods Eat smaller, plainer meals while symptoms last Cut back on sugar-free products containing sorbitol, mannitol, or xylitol Limit caffeine and alcohol Ask your healthcare provider before using over-the-counter anti-diarrhea medicine Contact your healthcare provider if diarrhea is severe, lasts more than a couple of days, or you notice signs of dehydration such as dark urine, dizziness, or urinating much less than usual

Science 179 , 7779 (1973)

20 This highlights the importance of using the medication period to build robust coping skills and healthy habits

10.3390/ph16060899 270 SmithB

Higher doses produce more noticeable retention