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Its FDA approval is built on this exact outcome, and the clinical evidence is robust

perfusion imaging reports microvascular reserve

Tajadura V, Hansen MH, Smith J, Charles H, Rickman M, Farrell-Dillon K, Claro V, Warboys C, Ferro A (2020) beta-catenin promotes endothelial survival by regulating eNOS activity and flow-dependent anti-apoptotic gene expression

This negative interaction might be related to the hyperhomocysteinemia-dependent increased thrombotic risk in subjects younger than 46 years and to the low response to the methionine load in older subjects

Obesity, vol 32(6): 1163-1168

J Appl Physiol (Bethesda, MD: 1985)