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Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

They point to the fact that FDA-approved biologic drugs carry comparable immunogenicity risks that are accepted under clinical monitoring

VCP is a conserved chaperone-like ATPase associated with protein unfolding activities by translocating ubiquitinated substrates through its central pore, which is formed by a homohexameric, ring-shaped complex

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These inclusion criteria (presence of fever and microbiologically confirmed bacterial infection) entail that some patients could not be included (such as patients with bacterial infection but who presented to the ED without fever), which might affect generalizability, but they were necessary to limit the heterogeneity of the patient population, given that this was a pilot study with a sample size of 100 patients

This conservative starting point allows assessment of individual response before increasing