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Depending on the dose, a fraction of APAP is converted into a highly reactive toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), by several P450 cytochromes [34]

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Most recommendations emphasize conservative dosage , timed cycles, and professional oversight

Most other NCEs under investigation follow traditional therapeutic avenues explored for uterine fibroids, which signals limited innovation: there are three GnRH antagonists, including merigolix (Phase II), and a selective progesterone receptor antagonist, telapristone, currently investigated in a Phase II study as a vaginal insert (both also investigated for endometriosis-related pain)

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Full hyperlink: North Tees and Hartlepool NHS Foundation Trust