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Although GPX4 depletion alone failed to affect HSCs function in vivo , Vav1- Gpx4 knockout mice fed with a vitamin E-depleted diet exhibited a reduced number of HSCs and dysregulated hematopoiesis, mainly due to increased ferroptosis [22]

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doi: 10.1016/j.bbrc.2015.05.059 51 SkowronMANiegischGAlbrechtPvan KoeveringeGRomanoAAlbersPet al

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Under these conditions, depending on the organism lactate and/or ethanol are produced from the pyruvate generated during glycolysis (fig

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