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Hence, BPC-157 is clearly on the do not compound for human use list

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Pharmacological inhibition of cyclophilin D is only effective before this threshold is crossed, defining a narrow therapeutic window (94)

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The authors themselves described it as a small preliminary study.[15] A 2025 pilot report described intravenous administration to two healthy adults at doses up to 20 mg, with no measurable changes in cardiac, hepatic, renal or thyroid biomarkers and no reported adverse effects.[16] Two individuals cannot characterise uncommon reactions, immunogenicity, long-term toxicity, reproductive safety or oncological risk