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TRIUMPH-3 (NCT05882045) will investigate change in bodyweight in people with overweight/obesity and cardiovascular disease, and TRIUMPH-4 (NCT05931367) will assess change in WOMAC score and bodyweight in individuals with overweight/obesity and knee OA
That's one reason doctors aren't always quick to dismiss the practice
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These variations are typically temporary and often resolve within 3-6 months as your body adapts to its new weight and hormone balance stabilizes
Human-focused reviews and meta-analyses have debated the magnitude and clinical relevance of lean mass changes during GLP-1RA therapy [41], whereas preclinical studies report context-dependent protection against muscle wasting [42, 43]
