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In patients with spinal deformities, such as idiopathic scoliosis and degenerative scoliosis, the apical vertebral region experiences stress concentration, resulting in higher grades of disc degeneration compared to other regions 10,27

doi:10.1177/17511437251327566

Another study focusing on individuals taking a 2.4 mg dose of semaglutide found that those who experienced diarrhea only dealt with the symptoms for about three days

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Also, rapid desensitization of surface receptors that are prevented from entering the endocytic pathway may be less relevant with agonists such as exendin-phe1, for which -arrestin recruitment is markedly reduced