Prohaska ES, Muzyk AJ, Rivelli SK
Doi:10.1002/jsfa.7147
Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic beta-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries
However, the well-recognized pleotropic effects of GLP-1R agonists (normalization of neurogenesis and synaptic plasticity, protection against neuronal apoptosis, and suppression of increased oxidative stress), in conjunction with the presence of GLP-1Rs in the hypothalamic nuclei that regulate sleep and wakefulness, suggest several possible direct effects of GLP-1R agonists in affecting sleepiness and other related parameters (memory, anxiety, and depression) [77, 114]
Adequate fluid intake should be maintained
As a nurse i understand proper procedures so recommend education