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This remains an open question for all senolytic therapies, not just FOXO4-DRI

J Chem Soc Trans

& Olzmann, J

Is it dietary intake, or is it absorption

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The Sikiric group has consistently characterized BPC-157 as resistant to degradation in human gastric juice, a property attributed to its compact 15-residue length, its five proline residues (which disrupt protease recognition motifs), and the absence of cysteine-bridgedependent tertiary structure (Sikiric et al., 2018)