Does adding B12 reduce the effectiveness of semaglutide
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For post-bariatric patients with residual cardiometabolic risk, this can be an important consideration, though it's not a separate licensed indication in the UK
In the trial, 201 adolescents with obesity were randomly assigned to once-weekly semaglutide 2.4 mg plus lifestyle intervention (n = 134) or placebo (n = 67) for 68 weeks
The mechanism of action involves binding to GLP-1 receptors on pancreatic beta cells, which stimulates glucose-dependent insulin secretion whilst simultaneously suppressing glucagon release
Like candy offered from the back of a van, its tempting, accessible, and depending on who you ask, may even appear harmless or beneficial