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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

Neovius M, Bruze G, Jacobson P, Sjholm K, Johansson K, Granath F, et al

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In preclinical work, BPC157 has been evaluated in cellbased and animal models where investigators examine structural integrity, barrier function, and responses to experimental tissue injury, strictly within controlled research settings

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HOLC would certainly feel the pain more than LOLC