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endpoints A and Z) added with 498 l of RPMI 1640 culture medium (Sigma-Aldrich, Saint Louis, Missouri) and 2 l of pH 5 citrate-phosphate buffer excipient (Merck, Darmstadt, Germany)
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Overall, both the timing and dosage of circadian-modulating interventions are critical determinants of efficacy, with timing governing circadian alignment and dosage shaping the magnitude of metabolic and antioxidant responses
Mundra, P
Frias JP, Nauck MA, Van J, et al
There is, however, a short-term spike in thyroid cancer diagnoses within the first year of initiation, likely due to increased surveillance (i.e., more thyroid ultrasounds and monitoring), not a direct causal effect
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