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Most research-community protocols cap on-time at 4-6 weeks with at least equal time off between cycles

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Xue et al., 2004

Pre-clinical vs Clinical Translation Challenges Concentrations that produce robust in-vitro fibroblast responses may not translate predictably to in-vivo or human contexts

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Timing Optional Marker ESR Why it matters Adds a slower-moving inflammation marker that may be useful when symptoms are chronic