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Although metformin increased GLP-1R level, exendin (939) or GLP-1R siRNA did not attenuate the protective effects of metformin in PA-impaired HUVECs, suggesting that metformin per se could not exert protective effects via GLP-1R, instead, metformin upregulated GLP-1R to enhance the protective effects of liraglutide on endothelial function

Some experimental patches use chemical penetration enhancers or dissolvable needle arrays, but these approaches add complexity and cost without yet achieving reliable therapeutic levels

These include: Self-administered drugs: Tablets, capsules, inhalers, eye drops, transdermal patches, nasal sprays, and injectables that patients give themselves (insulin pens, epinephrine pens, GLP-1 injections, etc.) ( [1] )

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