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With its unique "triple agonist" mechanism, it could redefine what is possible for patients with significant weight to lose

The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)

Thus Toft-Nielsen et al

This validated the start low, go slow approach thats now standard in all the Phase 3 trials

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