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Shortly after folic acid fortification was introduced, concerns were raised that higher intake might promote the progression of preneoplastic lesions in the colon (early cellular changes that could become cancer)

The mechanisms that drive this association include systemic inflammation, endothelial dysfunction, oxidative stress, hypertension, and metabolic dysfunction

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Women should search for a product containing at least 400 mcg (micrograms) of folate, 18 mg of iron, 150 mcg of iodine, 300 mg of chlorine, and a minimum of 600 IU vitamin D