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"Blocking FPN1 degradation" (e.g., USP35 activators or RNF217/DTX3L inhibitors) may emerge as a new strategy to sensitize solid tumors such as lung and renal cancer to ferroptosis therapy

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Carnitine and acylcarnitines are exchanged between different tissues as metabolic intermediates or signaling molecules, directly or indirectly affecting a variety of metabolic and biological pathways in almost all organs, and have broad impacts on interorgan communication and metabolic cooperation

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