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This concept is supported by our findings in obese Bbs5 / mice, which exhibit additional downregulation of Cck , Cckbr , Stat3 , and Socs3 expression, indicating that impaired leptin and CCK signaling contributes to the hyperphagia observed in BBS

In conclusion, the effects of GLP-1Ra (i.e., semaglutide and liraglutide), including weight loss, slight BMD loss, and increased CTX, resembled to those observed with calorie restriction interventions [7, 9]

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