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In vitro and animal-based studies have explored AOD-9604's interactions with osteoblast and osteoclast activity, investigating its role in bone remodeling pathways independent of IGF-1 signaling

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For instance, in April 2025, Pfizer, a US-based pharmaceutical company specializing in metabolic and cardiometabolic drug development, provided an update on its oral GLP-1 receptor agonist candidate, danuglipron, following the completion of once-daily formulation studies intended to improve dosing convenience for patients

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