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These preclinical findings further implicate glucagon activation as the distinguishing factor between incretin receptor mono-, dual-, and triagonists, and they point to unimolecular polypharmacology as an efficient way to target several mechanisms causing obesity

Patients on liver, kidney, or cardiovascular surgery need medical approval

L-Carnitine is most effective when taken 30 to 60 minutes before cardiovascular exercise

Qualifying conditions include type 2 diabetes, prediabetes, high blood pressure, high cholesterol, sleep apnea, PCOS, fatty liver disease, cardiovascular disease, insulin resistance, metabolic syndrome, and weight-related joint pain

Elife 9 , e56580 (2020)