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CURRENT ANTI-OBESITY PHARMACOTHERAPY Anti-obesity pharmacotherapy is indicated as an adjunct to lifestyle interventions in adults with a BMI 30 kg/m 2 or a BMI 27 kg/m 2 in patients with additional weight-related comorbidities
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90 A recent clinical trial assessing the histological benefits of tirzepatide for MASH reported that tirzepatide 5 mg achieved at least one-stage improvement in fibrosis for 55% of patients without worsening MASH, and 43.6% of patients experienced MASH resolution with no worsening fibrosis
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The suggested starting dose is around 0.25-0.5 mg per day
