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The metabolome-wide signature of major depressive disorder

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Proteins involved in the synthesis of polyol aldoreductase (AKR1B1), glycan and protein glycosylation through hexosamine biosynthetic pathway glutamine-fructose-6-phosphate aminotransferase (GFPT2) and essential protein in the purine salvage pathway, hypoxanthineguanine phosphoribosyltransferase (HPRT1) were also upregulated in OVCAR5 CBPR compared to OVCAR5 parental cells (Table 1)