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Retatrutide is an investigational triple incretin receptor agonist acting on GLP-1, GIP, and glucagon receptors currently undergoing clinical trials for the treatment of obesity and type 2 diabetes

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SLH reports support by grants from the National Institutes of Health and Office of Dietary Supplements (P20HL113452 and R01HL103866)

The T allele was associated with reduced risk of T2D, and increased likelihood of having been a smokerobservations that are consistent with public data

Some patients report that leg cramps worsen after dose increases, suggesting a dose-dependent relationship, though this remains an individual variation rather than a universal effect

Mounjaro already significantly reduces appetite and caloric intake through its mechanism of action