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The phosphorylated KD recruits cytosolic effector proteins, leading to activation of downstream signaling pathways
Current Neuropharmacology , 14(8), 857-865
A., Amorim, F
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This structural observation indicates that HGF I is the activating ligand that promotes c-MET dimerization and activation, whereas HGF II plays an auxiliary role that strengthens the interaction between HGF I and c-MET II
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