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Under freezing conditions, starch undergoes retrogradation, and the long chains of amylose molecules and amylopectin recombine to form double helical polymers connected by hydrogen bonds, forming short linear crystals with a strong molecular structure that make it difficult to degrade by amylase in the gastrointestinal tract (Jane & Robyt 1984)

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These molecular modifications indicate that CBP reduces oxidative stress damage and prevents apoptosis of the epithelial lens, thus preventing cataract progression [107]

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Aggregation can change surface electron-transfer properties and expose catalytic interfaces that accelerate redox cycling [30, 31], potentially increasing oxidative stress and nanotoxicity even when the core material and chemical composition are unchanged [32, 33]

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