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For randomised clinical trials, the Jadad scale ( To complement the Jadad score, the Cochrane Risk of Bias Tool (RoB 2) (Sterne et al., 2019) was also used for RCTs to provide a domain-based qualitative evaluation, assessing risks related to selection, performance, detection, attrition, and reporting

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Peer review Peer review information Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

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[12] What little has appeared since is preclinical and mostly concerns engineered analogues rather than DSIP itself for instance, fusion constructs designed to survive in circulation and cross the blood-brain barrier, tested in chemically-induced insomnia models in mice

Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, et al