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GLP-1 and Appetite Regulation: The Role of Brain-Gut Signaling GLP-1 is not only produced in the gut but also acts in the brains hypothalamus, where it influences hunger and satiety signals

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In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)

GLP-1 receptor agonists are generally contraindicated in pregnancy and breastfeeding, and some have specific restrictions in severe renal impairment

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