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Data on the primary outcome, the composite of all-cause mortality and HF-related hospitalization, was pooled using a random effect meta-analysis with additional subgroup analyses

Upon receptor ligation, these motifs undergo phosphorylation, triggering the recruitment of inhibitory effectors containing Src homology 2 (SH2) domains

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In clinical trials, patients were sometimes allowed to stay at a lower dose for up to 8 weeks if needed to let side effects settle down