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Gluconeogenesis also allows the synthesis of glucose from other metabolites, such as amino- or fatty acids 52

However, sex differences were not assessed, and prebiotic efficacy may vary by sex

Epilepsy Res 108(3):367378 Caballero-Caballero A, Engel T, Martinez-Villarreal J et al (2013) Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain [J]

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GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids